The immune response from this catch-up schedule might be lower for the

6

additional strains (types 1 ,3 ,5 ,

6

A,

the full 4 doses of Prevnar IS 1". It's not known how medically important this difference is.

Certain strains of the pneumococcal bacteria

con couse serious, invasive disease that is

being seen more frequently today.

The doctors ot the Centers for Disease Control hove

recommended that children under 5 who have had o

full series of vaccinations with pneumococcol conjugate

vaccine should now get o dose of Prevnar 13'”, to

cover six more strains including the most common one

threatening young children today*

Invasive pneumococcal disease includes bacterial

meningitis, which remains a serious risk for

children up to oge 5. Pneumococcal meningitis

con cause death and long-term problems,

such os heoring loss.

INDICATION FOR PREVNAR 13'“

• Prevnar 13'“ is a vaccine approved for use in children

6

weeks through 5 years of age (prior to the

6

fh birthday).

• Prevnar 1

T

is indicated for active immunization for the prevention of invasive disease caused by 13 strains of

Streptococcus pneumoniae

( 1 ,3 ,4 ,5 ,

6

A,

6

B, 7F, 9V, 1 4 ,1 8C,

19A, 19F, and 23F).

IMPORTANT SAFETY INFORMATION FOR PREVNAR 13’“

• Prevnar 13'" should not be given to anyone with a severe allergic reaction to any component of Prevnar 13’“, Prevnar® (Pneumococcal 7-valent Conjugate Vaccine [Diphtheria

CRMW Protein]), or ony diphtheria toxoid-containing vaccine.

• Prevnar 13'” may not protect all individuals receiving the vaccine. Children with weakened immune systems may have a reduced immune response to Prevnar 13:".

A temporary pause of breathing following vaccination has been observed in some infants born prematurely.

• Tbe most commonly reported serious adverse events include bronchiolitis (an infection of the lungs) (0.9%, 1.1%), gastroenteritis (inflammation of the stomach and small

intestine) (0.9%, 0.9% ), and pneumonia (0.9%, 0.5%) for Prevnar 13'“ and Prevnar®, respectively.

• The most common side effects ore redness, swelling and tenderness at the injection site, fever, decreased appetite, irritability, increased sleep,

and decreased sleep. Any side effects associated with the vaccination should be reported to your child's health core provider.

• Ask your child's health care provider about the risks and benefits of Prevnar 13m. Only a health care provider can decide if

7 7

/ 9

Prevnar 13 “ is right for your child.

£ Y

i V C V T l C l V 1 J

You are encouraged to report negative side effects o f prescription drugs to the FDA. Visit www.fda.gov/medwatch, or

call I-800-FDA-I088. Please see Brief Summary o f Prescribing Information on reverse side.

FOR

MORE INFORMATION, ASK YOUR

CHILD'S DOCTOR OR GO TO WWW.PREVNAR13.COM/UPDATE

W y e t h *

Manufactured by W yeth Pharmaceuticals Inc.

Marketed by Pfizer Inc.

264589-01

© 2 0 1 0 Pfizer Inc.

All rights reserved

Marketed by Pfizer Inc.

Printed in U SA/M ay 2010